OS9 [The Human Chemical-Genetic Interaction Map Project]

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======= OS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OS9
  * **<color #00a2e8>Official Name</color>**: OS9 endoplasmic reticulum lectin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10956|10956]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13438|Q13438]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609677|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRKCSH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Hrd1p ubiquitin ligase complex|
|negative regulation of retrograde protein transport, ER to cytosol|
|protein retention in ER lumen|
|negative regulation of protein exit from endoplasmic reticulum|
|maintenance of protein localization in endoplasmic reticulum|
|negative regulation of ERAD pathway|
|regulation of retrograde protein transport, ER to cytosol|
|endoplasmic reticulum mannose trimming|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|protein demannosylation|
|protein alpha-1,2-demannosylation|
|endoplasmic reticulum quality control compartment|
|protein exit from endoplasmic reticulum|
|regulation of protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|protein deglycosylation|
|maintenance of protein localization in organelle|
|negative regulation of intracellular protein transport|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of intracellular transport|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|maintenance of protein location in cell|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|maintenance of location in cell|
|protease binding|
|maintenance of protein location|
|negative regulation of cellular protein localization|
|negative regulation of protein catabolic process|
|protein localization to endoplasmic reticulum|
|maintenance of location|
|carbohydrate binding|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|negative regulation of establishment of protein localization|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|negative regulation of catabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|protein targeting|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|proteolysis|
|transmembrane transport|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.99|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.89|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.82|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.77|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.84|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc3|DNAJC3]]|0.46|
|[[:human genes:u:ube2j1|UBE2J1]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OS9 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>