OS9
Gene Information
- Official Symbol: OS9
- Official Name: OS9 endoplasmic reticulum lectin
- Aliases and Previous Symbols: N/A
- Entrez ID: 10956
- UniProt: Q13438
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PRKCSH |
GO Terms
| Hrd1p ubiquitin ligase complex |
| negative regulation of retrograde protein transport, ER to cytosol |
| protein retention in ER lumen |
| negative regulation of protein exit from endoplasmic reticulum |
| maintenance of protein localization in endoplasmic reticulum |
| negative regulation of ERAD pathway |
| regulation of retrograde protein transport, ER to cytosol |
| endoplasmic reticulum mannose trimming |
| endoplasmic reticulum to cytosol transport |
| retrograde protein transport, ER to cytosol |
| protein demannosylation |
| protein alpha-1,2-demannosylation |
| endoplasmic reticulum quality control compartment |
| protein exit from endoplasmic reticulum |
| regulation of protein exit from endoplasmic reticulum |
| regulation of ERAD pathway |
| protein deglycosylation |
| maintenance of protein localization in organelle |
| negative regulation of intracellular protein transport |
| negative regulation of response to endoplasmic reticulum stress |
| negative regulation of proteasomal protein catabolic process |
| negative regulation of intracellular transport |
| ubiquitin-dependent ERAD pathway |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| maintenance of protein location in cell |
| regulation of response to endoplasmic reticulum stress |
| negative regulation of cellular protein catabolic process |
| ERAD pathway |
| maintenance of location in cell |
| protease binding |
| maintenance of protein location |
| negative regulation of cellular protein localization |
| negative regulation of protein catabolic process |
| protein localization to endoplasmic reticulum |
| maintenance of location |
| carbohydrate binding |
| negative regulation of protein transport |
| regulation of proteasomal protein catabolic process |
| negative regulation of establishment of protein localization |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of intracellular protein transport |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| response to endoplasmic reticulum stress |
| endoplasmic reticulum lumen |
| negative regulation of catabolic process |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| regulation of intracellular transport |
| negative regulation of proteolysis |
| protein targeting |
| regulation of protein catabolic process |
| glycoprotein metabolic process |
| negative regulation of transport |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of cellular protein localization |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| protein modification by small protein conjugation |
| regulation of cellular catabolic process |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| proteolysis |
| transmembrane transport |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| negative regulation of response to stimulus |
| cellular response to stress |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cryptotanshinone 12μM R05 exp227 | -1.99 |
| Cyclosporin-A 3μM R07 exp348 | -1.89 |
| Cyclosporin-A 0.8μM R07 exp347 | -1.82 |
| Caffeine 2600μM R08 exp463 | -1.76 |
| QNZ 0.01μM R08 exp439 | 1.77 |
| YM155 0.001μM R08 exp432 | 1.84 |
| Atovaquone 15μM R08 exp451 | 1.87 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6062
- Expression level (log2 read counts): 7.67
Expression Distribution
OS9 Expression in NALM6 Cells: 7.67
