OSBP [The Human Chemical-Genetic Interaction Map Project]

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======= OSBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSBP
  * **<color #00a2e8>Official Name</color>**: oxysterol binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5007|5007]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22059|P22059]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Oxysterol BP|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sterol transfer activity|
|oxysterol binding|
|sterol transporter activity|
|sterol binding|
|intracellular cholesterol transport|
|intracellular sterol transport|
|perinuclear endoplasmic reticulum|
|bile acid biosynthetic process|
|phosphatidylinositol-4-phosphate binding|
|intracellular lipid transport|
|bile acid metabolic process|
|cholesterol transport|
|sterol transport|
|steroid biosynthetic process|
|organic hydroxy compound transport|
|lipid binding|
|trans-Golgi network|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|protein domain specific binding|
|steroid metabolic process|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|lipid localization|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|cell junction|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|nucleolus|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|intracellular transport|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.96|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.84|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.62|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.5|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.31|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.3|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.28|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.25|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.98|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.97|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.95|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.8|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.75|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.73|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.71|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.73|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.81|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.87|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.91|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.551|
|[[:human genes:p:prim1|PRIM1]]|0.53|
|[[:human genes:c:chd4|CHD4]]|0.516|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.513|
|[[:human genes:p:psmb4|PSMB4]]|0.513|
|[[:human genes:c:copz1|COPZ1]]|0.506|
|[[:human genes:s:supt5h|SUPT5H]]|0.504|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.504|
|[[:human genes:c:copb1|COPB1]]|0.5|
|[[:human genes:p:polr2a|POLR2A]]|0.495|
|[[:human genes:i:ik|IK]]|0.487|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.484|
|[[:human genes:a:arcn1|ARCN1]]|0.481|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.478|
|[[:human genes:p:psmd3|PSMD3]]|0.474|
|[[:human genes:r:rad51|RAD51]]|0.473|
|[[:human genes:s:snrnp70|SNRNP70]]|0.471|
|[[:human genes:p:psma6|PSMA6]]|0.471|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.469|
|[[:human genes:s:slc4a1|SLC4A1]]|0.469|
|[[:human genes:c:copb2|COPB2]]|0.468|
|[[:human genes:p:pole|POLE]]|0.466|
|[[:human genes:c:copg1|COPG1]]|0.466|
|[[:human genes:c:copa|COPA]]|0.465|
|[[:human genes:c:cbwd3|CBWD3]]|0.463|
|[[:human genes:z:znf830|ZNF830]]|0.463|
|[[:human genes:s:sap30bp|SAP30BP]]|0.462|
|[[:human genes:c:cbwd6|CBWD6]]|0.462|
|[[:human genes:c:cactin|CACTIN]]|0.457|
|[[:human genes:t:ticrr|TICRR]]|0.456|
|[[:human genes:c:cacna1a|CACNA1A]]|0.455|
|[[:human genes:t:tfip11|TFIP11]]|0.454|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.452|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.451|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.451|
|[[:human genes:m:med14|MED14]]|0.45|
|[[:human genes:c:col2a1|COL2A1]]|0.448|
|[[:human genes:c:cbwd5|CBWD5]]|0.448|
|[[:human genes:n:nup160|NUP160]]|0.448|
|[[:human genes:s:sf3a2|SF3A2]]|0.445|
|[[:human genes:r:rpl34|RPL34]]|0.445|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.444|
|[[:human genes:a:aatf|AATF]]|0.442|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.441|
|[[:human genes:t:twistnb|TWISTNB]]|0.44|
|[[:human genes:c:cdh24|CDH24]]|0.438|
|[[:human genes:d:dhx38|DHX38]]|0.438|
|[[:human genes:l:lrr1|LRR1]]|0.432|
|[[:human genes:s:supt6h|SUPT6H]]|0.431|
|[[:human genes:p:psmb2|PSMB2]]|0.431|
|[[:human genes:m:mfsd12|MFSD12]]|0.431|
|[[:human genes:r:rrp15|RRP15]]|0.43|
|[[:human genes:n:nup205|NUP205]]|0.43|
|[[:human genes:c:cln6|CLN6]]|0.43|
|[[:human genes:o:orc6|ORC6]]|0.43|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.429|
|[[:human genes:t:tceb3c|TCEB3C]]|0.428|
|[[:human genes:n:nol10|NOL10]]|0.428|
|[[:human genes:c:cdca3|CDCA3]]|0.428|
|[[:human genes:c:chmp4b|CHMP4B]]|0.427|
|[[:human genes:s:slc6a17|SLC6A17]]|0.427|
|[[:human genes:c:cdc45|CDC45]]|0.426|
|[[:human genes:f:fam160a1|FAM160A1]]|0.426|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.425|
|[[:human genes:p:polr1a|POLR1A]]|0.425|
|[[:human genes:s:sys1|SYS1]]|0.424|
|[[:human genes:s:sf3a3|SF3A3]]|0.424|
|[[:human genes:r:rbm39|RBM39]]|0.423|
|[[:human genes:c:ctage4|CTAGE4]]|0.423|
|[[:human genes:a:acsf2|ACSF2]]|0.423|
|[[:human genes:g:golga6a|GOLGA6A]]|0.423|
|[[:human genes:s:stil|STIL]]|0.421|
|[[:human genes:m:mt1e|MT1E]]|0.421|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.42|
|[[:human genes:r:rpl35|RPL35]]|0.419|
|[[:human genes:c:c14orf93|C14orf93]]|0.418|
|[[:human genes:c:ccna2|CCNA2]]|0.418|
|[[:human genes:p:psmc2|PSMC2]]|0.416|
|[[:human genes:c:cdca5|CDCA5]]|0.416|
|[[:human genes:s:sart1|SART1]]|0.415|
|[[:human genes:u:utp3|UTP3]]|0.415|
|[[:human genes:p:pan3|PAN3]]|0.415|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.413|
|[[:human genes:a:ankle2|ANKLE2]]|0.413|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.413|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.413|
|[[:human genes:t:tsg101|TSG101]]|0.413|
|[[:human genes:v:vps54|VPS54]]|0.412|
|[[:human genes:c:cep192|CEP192]]|0.411|
|[[:human genes:p:polr2j2|POLR2J2]]|0.411|
|[[:human genes:r:rps5|RPS5]]|0.408|
|[[:human genes:g:gid4|GID4]]|0.408|
|[[:human genes:c:cdc6|CDC6]]|0.408|
|[[:human genes:c:cog4|COG4]]|0.408|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.407|
|[[:human genes:r:rpl9|RPL9]]|0.407|
|[[:human genes:n:napa|NAPA]]|0.405|
|[[:human genes:p:psmc4|PSMC4]]|0.405|
|[[:human genes:c:chaf1a|CHAF1A]]|0.405|
|[[:human genes:n:nol12|NOL12]]|0.405|
|[[:human genes:n:narfl|NARFL]]|0.404|
|[[:human genes:p:paf1|PAF1]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.404|
|[[:human genes:t:tyms|TYMS]]|0.403|
|[[:human genes:z:znf541|ZNF541]]|0.402|
|[[:human genes:n:npipb5|NPIPB5]]|0.402|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:r:rrp7a|RRP7A]]|0.401|
|[[:human genes:k:kctd17|KCTD17]]|0.4|
|[[:human genes:s:sdhaf2|SDHAF2]]|0.4|
|[[:human genes:a:akirin2|AKIRIN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1017
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSBP Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>