OSBP

Entrez Summary: N/A
UniProt Summary: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WYE-354 6μM R02 exp90	-2.96
BH1 1μM R04 exp169	-2.84
Oligomycin-A 20μM R00 exp26	-2.75
Pimelic-diphenylamide-106 5μM R00 exp28	-2.62
Bleomycin 5μM R08 exp459	-2.5
PU-H71 1μM R08 exp515	-2.31
Etoposide 1μM R00 exp19	-2.3
Etoposide 0.3μM R05 exp199	-2.28
Actinomycin-D 0.001μM R00 exp3	-2.25
Bortezomib 0.05μM R00 exp7	-1.98
Brefeldin A 0.02μM R00 exp8	-1.97
GSK461364A 0.1μM R03 exp126	-1.95
BI-6727 0.04μM R03 exp98	-1.89
Bafilomycin-A1 0.009μM R08 exp454	-1.87
Rotenone 20μM R00 exp34	-1.8
Atovaquone 15μM R08 exp451	-1.75
Monensin 0.3μM R08 exp507	-1.73
Nicotinamide 1000μM R03 exp101	1.71
UM0011500 5μM R05 exp245	1.73
BRD2 inhibitor II 20μM R07 exp341	1.81
Pifithrin-alpha 20μM R07 exp390	1.87
Heregulin-B 44ng/ml R08 exp486	1.91
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.95

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Oxysterol BP
PH

sterol transfer activity
oxysterol binding
sterol transporter activity
sterol binding
intracellular cholesterol transport
intracellular sterol transport
perinuclear endoplasmic reticulum
bile acid biosynthetic process
phosphatidylinositol-4-phosphate binding
intracellular lipid transport
bile acid metabolic process
cholesterol transport
sterol transport
steroid biosynthetic process
organic hydroxy compound transport
lipid binding
trans-Golgi network
organic hydroxy compound biosynthetic process
monocarboxylic acid biosynthetic process
protein domain specific binding
steroid metabolic process
lipid transport
carboxylic acid biosynthetic process
organic acid biosynthetic process
lipid localization
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
cell junction
lipid biosynthetic process
small molecule biosynthetic process
Golgi membrane
intracellular membrane-bounded organelle
perinuclear region of cytoplasm
nucleolus
carboxylic acid metabolic process
endoplasmic reticulum membrane
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process