SDHAF2

Entrez Summary: This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010].
UniProt Summary: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	1.73
Selumetinib 20μM R02 exp81	1.76
VER-155008 3.9μM R06 exp301	1.78
Docetaxel 0.002μM R01 exp45	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	2.07
Temozolomide 200μM R04 exp189	2.11
Dynasore 10μM R04 exp180	2.17

Global Fraction of Cell Lines Where Essential: 15/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein-FAD linkage
mitochondrial respiratory chain complex II assembly
respiratory chain complex II assembly
mitochondrial electron transport, succinate to ubiquinone
protein-cofactor linkage
negative regulation of epithelial to mesenchymal transition
tricarboxylic acid cycle
aerobic respiration
regulation of epithelial to mesenchymal transition
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
negative regulation of canonical Wnt signaling pathway
electron transport chain
ATP metabolic process
negative regulation of Wnt signaling pathway
protein dephosphorylation
energy derivation by oxidation of organic compounds
regulation of canonical Wnt signaling pathway
dephosphorylation
regulation of Wnt signaling pathway
mitochondrial matrix
generation of precursor metabolites and energy
mitochondrion organization
negative regulation of cell differentiation
cellular protein-containing complex assembly
nucleolus
negative regulation of developmental process
oxidation-reduction process
negative regulation of multicellular organismal process
mitochondrion
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
protein-containing complex assembly
negative regulation of response to stimulus