OSBPL2

• Official Symbol: OSBPL2
• Official Name: oxysterol binding protein like 2
• Aliases and Previous Symbols: N/A
• Entrez ID: 9885
• UniProt: Q9H1P3
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014].
• UniProt Summary: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (PubMed:11279184). Binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000269|PubMed:11279184, ECO:0000269|PubMed:17428193}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 2808
• Expression level (log2 read counts): 5.21

Expression Distribution

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OSBPL2 Expression in NALM6 Cells: 5.21