OSBPL8 [The Human Chemical-Genetic Interaction Map Project]

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======= OSBPL8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSBPL8
  * **<color #00a2e8>Official Name</color>**: oxysterol binding protein like 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114882|114882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZF1|Q9BZF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSBPL8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSBPL8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606736|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25- hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Oxysterol BP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylserine transfer activity|
|protein localization to nuclear pore|
|negative regulation of sequestering of triglyceride|
|protein localization to nuclear envelope|
|regulation of sequestering of triglyceride|
|sterol binding|
|sterol transporter activity|
|phospholipid transporter activity|
|negative regulation of lipid storage|
|phosphatidylserine acyl-chain remodeling|
|positive regulation of insulin receptor signaling pathway|
|positive regulation of cellular response to insulin stimulus|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylserine metabolic process|
|activation of protein kinase B activity|
|positive regulation of glucose import|
|negative regulation of lipid localization|
|positive regulation of glucose transmembrane transport|
|regulation of lipid storage|
|cholesterol binding|
|regulation of glucose import|
|phosphatidylserine binding|
|regulation of insulin receptor signaling pathway|
|sterol transport|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|phospholipid transport|
|fat cell differentiation|
|organophosphate ester transport|
|organic hydroxy compound transport|
|regulation of lipid localization|
|lipid binding|
|protein localization to nucleus|
|positive regulation of protein kinase B signaling|
|cellular modified amino acid metabolic process|
|positive regulation of transmembrane transport|
|regulation of protein kinase B signaling|
|nuclear membrane|
|negative regulation of cell migration|
|negative regulation of cell motility|
|lipid transport|
|glycerophospholipid metabolic process|
|negative regulation of cellular component movement|
|lipid localization|
|negative regulation of locomotion|
|activation of protein kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|positive regulation of protein kinase activity|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|anion transport|
|positive regulation of transferase activity|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|organophosphate metabolic process|
|regulation of cell motility|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.33|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.65|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11010
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSBPL8 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>