OSBPL8

Entrez Summary: N/A
UniProt Summary: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25- hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
Oxysterol BP

phosphatidylserine transfer activity
protein localization to nuclear pore
negative regulation of sequestering of triglyceride
protein localization to nuclear envelope
regulation of sequestering of triglyceride
sterol binding
sterol transporter activity
phospholipid transporter activity
negative regulation of lipid storage
phosphatidylserine acyl-chain remodeling
positive regulation of insulin receptor signaling pathway
positive regulation of cellular response to insulin stimulus
phosphatidylinositol-4-phosphate binding
phosphatidylserine metabolic process
activation of protein kinase B activity
positive regulation of glucose import
negative regulation of lipid localization
positive regulation of glucose transmembrane transport
regulation of lipid storage
cholesterol binding
regulation of glucose import
phosphatidylserine binding
regulation of insulin receptor signaling pathway
sterol transport
regulation of cellular response to insulin stimulus
regulation of glucose transmembrane transport
phospholipid transport
fat cell differentiation
organophosphate ester transport
organic hydroxy compound transport
regulation of lipid localization
lipid binding
protein localization to nucleus
positive regulation of protein kinase B signaling
cellular modified amino acid metabolic process
positive regulation of transmembrane transport
regulation of protein kinase B signaling
nuclear membrane
negative regulation of cell migration
negative regulation of cell motility