OSBPL9 [The Human Chemical-Genetic Interaction Map Project]

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======= OSBPL9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSBPL9
  * **<color #00a2e8>Official Name</color>**: oxysterol binding protein like 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114883|114883]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96SU4|Q96SU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSBPL9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSBPL9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606737|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Oxysterol BP|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sterol transporter activity|
|sterol binding|
|bile acid biosynthetic process|
|bile acid metabolic process|
|sterol transport|
|late endosome membrane|
|steroid biosynthetic process|
|organic hydroxy compound transport|
|lipid binding|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|steroid metabolic process|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|lipid localization|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|carboxylic acid metabolic process|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-4.48|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-3.35|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.24|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.33|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.89|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.86|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.78|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.77|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.76|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.88|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.17|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.41|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|4.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:osbpl11|OSBPL11]]|0.467|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSBPL9 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>