OSBPL9

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-4.48
CFI-400945 25μM R08 exp469	-3.35
Q15 2.7μM R02 exp79	-3.24
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.33
S-DABN 8μM R03 exp112	-1.89
BVD-523 15μM R02 exp67	-1.86
Golgicide-A 4μM R03 exp122	-1.78
Tubacin 1.6μM R07 exp416	-1.77
Metformin 100 to 150μM on day4 R04 exp170	-1.76
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.71
AICAR 240μM R03 exp116	1.88
Bafilomycin-A1 0.009μM R08 exp454	2.17
MK2206 4μM R08 exp504	2.41
Clomiphene 4.4μM R02 exp68	4.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Oxysterol BP
PH

sterol transporter activity
sterol binding
bile acid biosynthetic process
bile acid metabolic process
sterol transport
late endosome membrane
steroid biosynthetic process
organic hydroxy compound transport
lipid binding
organic hydroxy compound biosynthetic process
monocarboxylic acid biosynthetic process
steroid metabolic process
lipid transport
carboxylic acid biosynthetic process
organic acid biosynthetic process
lipid localization
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process
membrane