OSM

Gene Information

Official Symbol: OSM
Official Name: oncostatin M
Aliases and Previous Symbols: N/A
Entrez ID: 5008
UniProt: P13725
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:1542792, ECO:0000269|PubMed:1542793}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14944
Expression level (log2 read counts): -1.17

Expression Distribution

oncostatin-M receptor binding
positive regulation of interleukin-17 secretion
oncostatin-M-mediated signaling pathway
regulation of interleukin-17 secretion
positive regulation of interleukin-17 production
regulation of interleukin-17 production
positive regulation of acute inflammatory response
regulation of acute inflammatory response
negative regulation of hormone secretion
positive regulation of tyrosine phosphorylation of STAT protein
regulation of hematopoietic stem cell differentiation
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
regulation of hematopoietic progenitor cell differentiation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell division
positive regulation of receptor signaling pathway via STAT
positive regulation of peptidyl-serine phosphorylation
regulation of stem cell differentiation
regulation of phosphatidylinositol 3-kinase signaling
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
regulation of peptidyl-serine phosphorylation
positive regulation of cytokine secretion
positive regulation of inflammatory response
growth factor activity
positive regulation of protein kinase B signaling
regulation of cell division
cytokine activity
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion by cell
regulation of cytokine secretion
regulation of protein kinase B signaling
negative regulation of secretion
regulation of peptidyl-tyrosine phosphorylation
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
regulation of inflammatory response
positive regulation of secretion by cell