OSTN

Entrez Summary: N/A
UniProt Summary: Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). {ECO:0000250|UniProtKB:P61364, ECO:0000269|PubMed:27830782}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of dendrite extension
negative regulation of glucose import
negative regulation of glucose transmembrane transport
regulation of dendrite extension
endochondral bone growth
negative regulation of osteoblast differentiation
bone growth
regulation of glucose import
regulation of glucose transmembrane transport
negative regulation of ossification
organ growth
hormone activity
negative regulation of developmental growth
regulation of osteoblast differentiation
negative regulation of transmembrane transport
negative regulation of neuron projection development
hormone-mediated signaling pathway
negative regulation of cell projection organization
negative regulation of cell growth
regulation of ossification
negative regulation of neuron differentiation
negative regulation of growth
negative regulation of neurogenesis
negative regulation of nervous system development
regulation of developmental growth
negative regulation of cell development
developmental growth
growth
regulation of cell growth
negative regulation of transport
regulation of cell morphogenesis
regulation of neuron projection development
regulation of transmembrane transport
cellular response to hormone stimulus
regulation of neuron differentiation
regulation of growth
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation