OTC

Entrez Summary: This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

OTCace
OTCace N

ornithine carbamoyltransferase activity
ornithine catabolic process
response to biotin
ammonia homeostasis
arginine biosynthetic process via ornithine
citrulline biosynthetic process
arginine biosynthetic process
citrulline metabolic process
ornithine metabolic process
urea cycle
urea metabolic process
phosphate ion binding
nitrogen cycle metabolic process
midgut development
arginine metabolic process
amino acid binding
glutamine family amino acid biosynthetic process
protein homotrimerization
protein trimerization
response to zinc ion
anion homeostasis
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
response to vitamin
phospholipid binding
alpha-amino acid catabolic process
cellular amino acid catabolic process
liver development
hepaticobiliary system development
digestive tract development
digestive system development
alpha-amino acid metabolic process
response to nutrient
response to insulin
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process