OTOP1

Entrez Summary: N/A
UniProt Summary: Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 33/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	2/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	5/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of gravity
proton channel activity
negative regulation of response to interferon-gamma
negative regulation of interferon-gamma-mediated signaling pathway
response to gravity
regulation of response to interferon-gamma
regulation of interferon-gamma-mediated signaling pathway
negative regulation of innate immune response
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
biomineralization
negative regulation of response to biotic stimulus
biomineral tissue development
inner ear morphogenesis
ear morphogenesis
detection of external stimulus
detection of abiotic stimulus
proton transmembrane transport
negative regulation of immune response
cellular response to insulin stimulus
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
inner ear development
negative regulation of defense response
negative regulation of multi-organism process
ear development
response to insulin
sensory organ morphogenesis
cellular response to peptide hormone stimulus
embryonic organ morphogenesis
cellular response to peptide
negative regulation of response to external stimulus
response to peptide hormone
monovalent inorganic cation transport
embryonic organ development
negative regulation of immune system process
regulation of innate immune response
response to peptide
regulation of response to biotic stimulus
sensory organ development