OTP

Entrez Summary: N/A
UniProt Summary: Probably involved in the differentiation of hypothalamic neuroendocrine cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
OAR

neurohypophysis development
hypothalamus cell differentiation
positive regulation of neuroblast proliferation
hypothalamus development
regulation of neuroblast proliferation
positive regulation of stem cell proliferation
pituitary gland development
forebrain neuron differentiation
positive regulation of neural precursor cell proliferation
regulation of stem cell proliferation
forebrain generation of neurons
diencephalon development
regulation of neural precursor cell proliferation
limbic system development
endocrine system development
central nervous system neuron differentiation
forebrain development
gland development
sequence-specific DNA binding
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
brain development
head development
regulation of neurogenesis
positive regulation of cell population proliferation
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
neuron differentiation
positive regulation of developmental process
generation of neurons
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation