OXER1

Entrez Summary: N/A
UniProt Summary: Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. {ECO:0000269|PubMed:12065583, ECO:0000269|PubMed:12606753}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	-1.93
Nutlin-3A 1.6μM R06 exp294	-1.87
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.77
Atovaquone 15μM R08 exp451	-1.77
Lapatinib 5μM R01 exp47	1.88
BI-2536 0.001μM R01 exp41	2.27

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
G protein-coupled receptor activity
G protein-coupled receptor signaling pathway