P2RX3
Gene Information
- Official Symbol: P2RX3
- Official Name: purinergic receptor P2X 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5024
- UniProt: P56373
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for ATP that acts as a ligand-gated ion channel.
Pfam Domains GO Terms
Pfam Domains
| P2X receptor |
GO Terms
| behavioral response to formalin induced pain |
| behavioral response to chemical pain |
| ATP-gated ion channel activity |
| urinary tract smooth muscle contraction |
| purinergic nucleotide receptor activity |
| urinary bladder smooth muscle contraction |
| positive regulation of sensory perception of pain |
| extracellularly ATP-gated cation channel activity |
| peristalsis |
| behavioral response to pain |
| integral component of nuclear inner membrane |
| chemosensory behavior |
| phasic smooth muscle contraction |
| cellular response to ATP |
| purinergic nucleotide receptor signaling pathway |
| purinergic receptor signaling pathway |
| neuronal action potential |
| response to pain |
| response to ATP |
| protein homotrimerization |
| neuromuscular synaptic transmission |
| hippocampal mossy fiber to CA3 synapse |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| positive regulation of calcium-mediated signaling |
| terminal bouton |
| response to cold |
| smooth muscle contraction |
| positive regulation of calcium ion transport into cytosol |
| protein trimerization |
| transmission of nerve impulse |
| integral component of presynaptic membrane |
| rough endoplasmic reticulum |
| positive regulation of nervous system process |
| excitatory postsynaptic potential |
| sensory perception of taste |
| chemical synaptic transmission, postsynaptic |
| cellular response to nutrient |
| multicellular organismal response to stress |
| Schaffer collateral - CA1 synapse |
| action potential |
| regulation of calcium-mediated signaling |
| regulation of calcium ion transport into cytosol |
| regulation of postsynaptic membrane potential |
| response to heat |
| positive regulation of calcium ion transport |
| multicellular organismal signaling |
| response to organophosphorus |
| regulation of nervous system process |
| dendritic spine |
| response to purine-containing compound |
| response to carbohydrate |
| response to temperature stimulus |
| regulation of synaptic plasticity |
| receptor complex |
| response to mechanical stimulus |
| response to nutrient |
| membrane raft |
| cellular response to nutrient levels |
| regulation of calcium ion transport |
| muscle contraction |
| cellular response to extracellular stimulus |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| blood coagulation |
| coagulation |
| hemostasis |
| muscle system process |
| regulation of cytosolic calcium ion concentration |
| cellular response to external stimulus |
| protein homooligomerization |
| response to hypoxia |
| response to decreased oxygen levels |
| neuronal cell body |
| response to oxygen levels |
| regulation of metal ion transport |
| monovalent inorganic cation transport |
| cellular response to drug |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| response to nutrient levels |
| protein complex oligomerization |
| response to extracellular stimulus |
| sensory perception of chemical stimulus |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| response to wounding |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| ion transmembrane transport |
| sensory perception |
| Golgi apparatus |
| positive regulation of transport |
| response to organonitrogen compound |
| positive regulation of intracellular signal transduction |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| response to endogenous stimulus |
| ATP binding |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Celastrol 0.12μM R05 exp225 | 2.01 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8258
- Expression level (log2 read counts): -0.28
Expression Distribution
P2RX3 Expression in NALM6 Cells: -0.28
