P2RX6

Entrez Summary: N/A
UniProt Summary: Receptor for ATP that acts as a ligand-gated ion channel. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

purinergic nucleotide receptor activity
ATP-gated ion channel activity
extracellularly ATP-gated cation channel activity
channel activity
integral component of nuclear inner membrane
parallel fiber to Purkinje cell synapse
purinergic nucleotide receptor signaling pathway
integral component of postsynaptic specialization membrane
purinergic receptor signaling pathway
response to ATP
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
regulation of postsynaptic membrane potential
protein heterooligomerization
response to organophosphorus
transmembrane signaling receptor activity
dendritic spine
response to purine-containing compound
response to nutrient
muscle contraction
postsynaptic density
blood coagulation
coagulation
hemostasis
muscle system process
protein homooligomerization
glutamatergic synapse
neuronal cell body
chemical synaptic transmission
anterograde trans-synaptic signaling
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
wound healing
regulation of body fluid levels
response to nutrient levels
protein complex oligomerization
response to extracellular stimulus
cell junction