P2RY13

Entrez Summary: N/A
UniProt Summary: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. {ECO:0000269|PubMed:11546776}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
39°C R06 exp303	-1.77
Hypoxia 5%O2 R04 exp191	1.74

7tm 1
7TM GPCR Srv

G protein-coupled purinergic nucleotide receptor activity
G protein-coupled purinergic nucleotide receptor signaling pathway
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
G protein-coupled purinergic receptor signaling pathway
purinergic nucleotide receptor signaling pathway
negative regulation of lyase activity
purinergic receptor signaling pathway
regulation of adenylate cyclase activity
regulation of cyclase activity
regulation of lyase activity
cellular response to organic cyclic compound
negative regulation of catalytic activity
response to organic cyclic compound
endoplasmic reticulum
negative regulation of molecular function
G protein-coupled receptor signaling pathway