P2RY6 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RY6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RY6
  * **<color #00a2e8>Official Name</color>**: pyrimidinergic receptor P2Y6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5031|5031]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15077|Q15077]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RY6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RY6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602451|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to pyrimidine ribonucleotide|
|response to pyrimidine ribonucleotide|
|ADP receptor activity|
|UTP-activated nucleotide receptor activity|
|UDP-activated nucleotide receptor activity|
|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|transepithelial chloride transport|
|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|positive regulation of inositol trisphosphate biosynthetic process|
|regulation of inositol trisphosphate biosynthetic process|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|cellular response to purine-containing compound|
|positive regulation of inositol phosphate biosynthetic process|
|cellular response to prostaglandin E stimulus|
|regulation of inositol phosphate biosynthetic process|
|transepithelial transport|
|G protein-coupled purinergic receptor signaling pathway|
|purinergic nucleotide receptor signaling pathway|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|positive regulation of alcohol biosynthetic process|
|purinergic receptor signaling pathway|
|response to prostaglandin|
|activation of phospholipase C activity|
|positive regulation of vascular smooth muscle cell proliferation|
|positive regulation of smooth muscle cell migration|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of phospholipase C activity|
|positive regulation of calcium-mediated signaling|
|regulation of phospholipase C activity|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of calcium ion transport into cytosol|
|cellular response to fatty acid|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of phospholipase activity|
|regulation of smooth muscle cell migration|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|regulation of alcohol biosynthetic process|
|regulation of release of sequestered calcium ion into cytosol|
|positive regulation of carbohydrate metabolic process|
|response to fatty acid|
|cellular response to alcohol|
|positive regulation of smooth muscle cell proliferation|
|regulation of calcium ion transmembrane transporter activity|
|cellular response to ketone|
|regulation of carbohydrate biosynthetic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of calcium-mediated signaling|
|regulation of lipase activity|
|regulation of calcium ion transport into cytosol|
|chloride transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|regulation of smooth muscle cell proliferation|
|response to organophosphorus|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|response to purine-containing compound|
|positive regulation of ion transmembrane transport|
|inorganic anion transport|
|regulation of cation channel activity|
|response to ketone|
|basolateral plasma membrane|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|cellular response to acid chemical|
|positive regulation of ERK1 and ERK2 cascade|
|response to alcohol|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|apical plasma membrane|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|regulation of cation transmembrane transport|
|response to acid chemical|
|regulation of metal ion transport|
|regulation of small molecule metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RY6 Expression in NALM6 Cells: 0.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>