P2RY6
Gene Information
- Official Symbol: P2RY6
- Official Name: pyrimidinergic receptor P2Y6
- Aliases and Previous Symbols: N/A
- Entrez ID: 5031
- UniProt: Q15077
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| cellular response to pyrimidine ribonucleotide |
| response to pyrimidine ribonucleotide |
| ADP receptor activity |
| UTP-activated nucleotide receptor activity |
| UDP-activated nucleotide receptor activity |
| positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| transepithelial chloride transport |
| regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| positive regulation of inositol trisphosphate biosynthetic process |
| regulation of inositol trisphosphate biosynthetic process |
| G protein-coupled purinergic nucleotide receptor signaling pathway |
| cellular response to purine-containing compound |
| positive regulation of inositol phosphate biosynthetic process |
| cellular response to prostaglandin E stimulus |
| regulation of inositol phosphate biosynthetic process |
| transepithelial transport |
| G protein-coupled purinergic receptor signaling pathway |
| purinergic nucleotide receptor signaling pathway |
| cellular response to prostaglandin stimulus |
| response to prostaglandin E |
| positive regulation of alcohol biosynthetic process |
| purinergic receptor signaling pathway |
| response to prostaglandin |
| activation of phospholipase C activity |
| positive regulation of vascular smooth muscle cell proliferation |
| positive regulation of smooth muscle cell migration |
| positive regulation of calcium ion transmembrane transporter activity |
| positive regulation of release of sequestered calcium ion into cytosol |
| positive regulation of phospholipase C activity |
| positive regulation of calcium-mediated signaling |
| regulation of phospholipase C activity |
| regulation of vascular smooth muscle cell proliferation |
| positive regulation of calcium ion transport into cytosol |
| cellular response to fatty acid |
| positive regulation of cellular carbohydrate metabolic process |
| positive regulation of phospholipase activity |
| regulation of smooth muscle cell migration |
| positive regulation of cation channel activity |
| positive regulation of calcium ion transmembrane transport |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| regulation of alcohol biosynthetic process |
| regulation of release of sequestered calcium ion into cytosol |
| positive regulation of carbohydrate metabolic process |
| response to fatty acid |
| cellular response to alcohol |
| positive regulation of smooth muscle cell proliferation |
| regulation of calcium ion transmembrane transporter activity |
| cellular response to ketone |
| regulation of carbohydrate biosynthetic process |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of calcium-mediated signaling |
| regulation of lipase activity |
| regulation of calcium ion transport into cytosol |
| chloride transport |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| regulation of smooth muscle cell proliferation |
| response to organophosphorus |
| positive regulation of small molecule metabolic process |
| regulation of cellular carbohydrate metabolic process |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| response to purine-containing compound |
| positive regulation of ion transmembrane transport |
| inorganic anion transport |
| regulation of cation channel activity |
| response to ketone |
| basolateral plasma membrane |
| positive regulation of transmembrane transport |
| regulation of carbohydrate metabolic process |
| cellular response to acid chemical |
| positive regulation of ERK1 and ERK2 cascade |
| response to alcohol |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| apical plasma membrane |
| regulation of cytosolic calcium ion concentration |
| phagocytosis |
| regulation of cation transmembrane transport |
| response to acid chemical |
| regulation of metal ion transport |
| regulation of small molecule metabolic process |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| positive regulation of cell migration |
| cellular response to lipid |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| anion transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of cell migration |
| response to lipid |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| ion transport |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11257
- Expression level (log2 read counts): 0.68
Expression Distribution
P2RY6 Expression in NALM6 Cells: 0.68
