PA2G4 [The Human Chemical-Genetic Interaction Map Project]

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======= PA2G4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PA2G4
  * **<color #00a2e8>Official Name</color>**: proliferation-associated 2G4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5036|5036]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ80|Q9UQ80]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PA2G4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PA2G4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M24|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|azurophil granule lumen|
|nucleic acid binding|
|rRNA processing|
|rRNA metabolic process|
|ubiquitin protein ligase binding|
|ribosome biogenesis|
|regulation of translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|DNA-binding transcription factor activity|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|nucleolus|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of cell differentiation|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.14|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.99|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.74|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.72|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.72|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.06|
|[[:results:exp302|35°C R06 exp302]]|2.27|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.45|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.89|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PA2G4 Expression in NALM6 Cells: 8.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>