PA2G4

Entrez Summary: N/A
UniProt Summary: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-2.14
Fluvastatin 2.2μM R06 exp282	-1.99
Colchicine 0.009μM R05 exp215	-1.74
2-Methoxyestradiol 0.55μM R07 exp310	-1.72
Bisphenol A 100μM R06 exp269	1.72
5-Fluorouracil 2μM R00 exp1	1.79
Mubritinib 0.2μM R01 exp48	1.94
AICAR 240μM R03 exp116	2.06
35°C R06 exp302	2.27
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.45
MS023 7μM R03 exp135	2.89
MS023 2μM R03 exp134	2.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

azurophil granule lumen
nucleic acid binding
rRNA processing
rRNA metabolic process
ubiquitin protein ligase binding
ribosome biogenesis
regulation of translation
ncRNA processing
regulation of cellular amide metabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
posttranscriptional regulation of gene expression
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
DNA-binding transcription factor activity
regulated exocytosis
leukocyte mediated immunity
exocytosis
nucleolus
RNA processing
negative regulation of apoptotic process
negative regulation of programmed cell death
leukocyte activation
positive regulation of cell differentiation
negative regulation of cell death
secretion by cell
export from cell
cell activation
immune effector process
secretion
negative regulation of transcription, DNA-templated