PABPC4 [The Human Chemical-Genetic Interaction Map Project]

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======= PABPC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PABPC4
  * **<color #00a2e8>Official Name</color>**: poly(A) binding protein cytoplasmic 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8761|8761]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13310|Q13310]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PABPC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PABPC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603407|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PABP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(C) RNA binding|
|poly(A) binding|
|poly(U) RNA binding|
|myeloid cell development|
|cytoplasmic stress granule|
|mRNA 3-UTR binding|
|ribonucleoprotein complex|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|myeloid cell differentiation|
|RNA catabolic process|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|wound healing|
|organic cyclic compound catabolic process|
|regulation of body fluid levels|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|hemopoiesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|immune system development|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.98|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.88|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.75|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.77|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.83|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.83|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.98|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PABPC4 Expression in NALM6 Cells: 8.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>