PABPC4

Entrez Summary: N/A
UniProt Summary: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PABP
RRM 1

poly(C) RNA binding
poly(A) binding
poly(U) RNA binding
myeloid cell development
cytoplasmic stress granule
mRNA 3-UTR binding
ribonucleoprotein complex
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
myeloid cell differentiation
RNA catabolic process
blood coagulation
coagulation
hemostasis
regulation of mRNA metabolic process
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
wound healing
organic cyclic compound catabolic process
regulation of body fluid levels
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
hemopoiesis
response to wounding
hematopoietic or lymphoid organ development
immune system development
cellular amide metabolic process
regulation of cellular catabolic process
RNA processing
cellular macromolecule catabolic process
regulation of catabolic process
macromolecule catabolic process
RNA binding
organonitrogen compound biosynthetic process