PACSIN2

Entrez Summary: N/A
UniProt Summary: Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

caveola assembly
caveolin-mediated endocytosis
plasma membrane raft assembly
plasma membrane raft organization
membrane raft assembly
protein localization to endosome
plasma membrane tubulation
phosphatidic acid binding
membrane raft organization
membrane assembly
membrane biogenesis
transporter activity
negative regulation of endocytosis
extrinsic component of membrane
caveola
cytoskeletal protein binding
recycling endosome membrane
plasma membrane organization
ruffle membrane
phospholipid binding
cytoplasmic vesicle membrane
cell-cell junction
regulation of endocytosis
early endosome
cadherin binding
glutamatergic synapse
cytoskeleton
nuclear speck
focal adhesion
endomembrane system organization
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
negative regulation of transport
cell projection morphogenesis
actin cytoskeleton organization
cell part morphogenesis
regulation of vesicle-mediated transport
endocytosis
actin filament-based process
import into cell