PAFAH1B2 [The Human Chemical-Genetic Interaction Map Project]

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======= PAFAH1B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAFAH1B2
  * **<color #00a2e8>Official Name</color>**: platelet activating factor acetylhydrolase 1b catalytic subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5049|5049]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68402|P68402]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAFAH1B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAFAH1B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipase GDSL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet-activating factor acetyltransferase activity|
|1-alkyl-2-acetylglycerophosphocholine esterase activity|
|positive regulation of macroautophagy|
|secretory granule lumen|
|positive regulation of autophagy|
|ficolin-1-rich granule lumen|
|fibrillar center|
|regulation of macroautophagy|
|lipid catabolic process|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|spermatogenesis|
|male gamete generation|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|gamete generation|
|regulated exocytosis|
|brain development|
|leukocyte mediated immunity|
|head development|
|exocytosis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|nucleolus|
|protein homodimerization activity|
|leukocyte activation|
|central nervous system development|
|multi-organism reproductive process|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|reproductive process|
|reproduction|
|organic substance catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.47|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.39|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.23|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.99|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.99|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.9|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.87|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.82|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.76|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.74|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAFAH1B2 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>