PAFAH1B2

Official Symbol: PAFAH1B2
Official Name: platelet activating factor acetylhydrolase 1b catalytic subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 5049
UniProt: P68402
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.1μM R01 exp49	-2.47
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.39
Nicotinamide 2000μM R01 exp50	-2.23
Bortezomib 0.05μM R00 exp7	-1.99
Vitamin-D3 40μM R08 exp536	-1.99
Nifurtimox 1μM R03 exp141	-1.9
Hydroxyurea 100μM R07 exp329	-1.87
Pifithrin-alpha 20μM R07 exp390	-1.82
ML-792 0.2μM R08 exp505	-1.76
BI-2536 0.001μM R01 exp41	-1.74
Daidzin 10μM R06 exp280	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet-activating factor acetyltransferase activity
1-alkyl-2-acetylglycerophosphocholine esterase activity
positive regulation of macroautophagy
secretory granule lumen
positive regulation of autophagy
ficolin-1-rich granule lumen
fibrillar center
regulation of macroautophagy
lipid catabolic process
regulation of autophagy
positive regulation of cellular catabolic process
positive regulation of catabolic process
neutrophil degranulation
protein heterodimerization activity
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
spermatogenesis
male gamete generation
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
gamete generation
regulated exocytosis
brain development
leukocyte mediated immunity
head development
exocytosis
multicellular organismal reproductive process
sexual reproduction
regulation of cellular catabolic process
multicellular organism reproduction
nucleolus
protein homodimerization activity
leukocyte activation
central nervous system development