PAICS [The Human Chemical-Genetic Interaction Map Project]

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======= PAICS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAICS
  * **<color #00a2e8>Official Name</color>**: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10606|10606]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22234|P22234]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAICS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAICS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172439|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAICAR synt|
|AIRC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoribosylaminoimidazole carboxylase activity|
|5-amino-4-imidazole carboxylate lyase activity|
|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity|
|de novo IMP biosynthetic process|
|IMP biosynthetic process|
|purine nucleobase biosynthetic process|
|IMP metabolic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pigment metabolic process|
|nucleoside monophosphate metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cadherin binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.99|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.82|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.74|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.71|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.76|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 73/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|6/28|
|bone|1/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|4/21|
|liver|0/20|
|lung|13/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 259
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAICS Expression in NALM6 Cells: 8.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>