PAICS

Gene Information

Official Symbol: PAICS
Official Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Aliases and Previous Symbols: N/A
Entrez ID: 10606
UniProt: P22234
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CAY10603 0.55μM R08 exp467	-1.99
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.82
Mitomycin-C 0.06μM R08 exp503	-1.74
Hydroxychloroquine 30μM R08 exp490	1.71
MS023 7μM R03 exp135	1.76
Aphidicolin 0.04μM R06 exp263	1.78
Temozolomide 200μM R04 exp189	2.48

Global Fraction of Cell Lines Where Essential: 73/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	6/28
bone	1/26
breast	6/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	4/21
liver	0/20
lung	13/75
lymphocyte	4/16
ovary	1/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 259
Expression level (log2 read counts): 8.64

Expression Distribution

SAICAR synt
AIRC

phosphoribosylaminoimidazole carboxylase activity
5-amino-4-imidazole carboxylate lyase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
de novo IMP biosynthetic process
IMP biosynthetic process
purine nucleobase biosynthetic process
IMP metabolic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
nucleobase biosynthetic process
purine nucleobase metabolic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
pigment biosynthetic process
ribonucleoside monophosphate metabolic process
pigment metabolic process
nucleoside monophosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
cadherin binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
carbohydrate derivative metabolic process