PALM [The Human Chemical-Genetic Interaction Map Project]

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======= PALM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PALM
  * **<color #00a2e8>Official Name</color>**: paralemmin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5064|5064]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75781|O75781]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PALM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PALM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608134|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Paralemmin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D3 dopamine receptor binding|
|negative regulation of dopamine receptor signaling pathway|
|intrinsic component of the cytoplasmic side of the plasma membrane|
|regulation of dopamine receptor signaling pathway|
|cellular response to electrical stimulus|
|synapse maturation|
|dendritic spine membrane|
|filopodium membrane|
|apicolateral plasma membrane|
|negative regulation of adenylate cyclase activity|
|negative regulation of cellular response to drug|
|negative regulation of cyclase activity|
|negative regulation of lyase activity|
|regulation of adenylate cyclase activity|
|negative regulation of response to drug|
|positive regulation of filopodium assembly|
|regulation of cellular response to drug|
|response to electrical stimulus|
|regulation of cyclase activity|
|regulation of filopodium assembly|
|regulation of lyase activity|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of response to drug|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of cell shape|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|protein localization to cell periphery|
|developmental maturation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|postsynaptic density|
|cytoplasmic vesicle|
|synapse organization|
|axon|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|positive regulation of cell projection organization|
|protein localization to membrane|
|regulation of cell morphogenesis|
|positive regulation of cellular component biogenesis|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of catalytic activity|
|regulation of cellular component biogenesis|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.93|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.77|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.602|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3438
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PALM Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>