PALM

Gene Information

Official Symbol: PALM
Official Name: paralemmin
Aliases and Previous Symbols: N/A
Entrez ID: 5064
UniProt: O75781
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3438
Expression level (log2 read counts): 1.5

Expression Distribution

Screen	Score
HMS-I2 5μM R06 exp287	-1.93
Tenofovir 10μM R07 exp405	-1.77
Apcin 50 to 100μM on day4 R04 exp176	2.45

D3 dopamine receptor binding
negative regulation of dopamine receptor signaling pathway
intrinsic component of the cytoplasmic side of the plasma membrane
regulation of dopamine receptor signaling pathway
cellular response to electrical stimulus
synapse maturation
dendritic spine membrane
filopodium membrane
apicolateral plasma membrane
negative regulation of adenylate cyclase activity
negative regulation of cellular response to drug
negative regulation of cyclase activity
negative regulation of lyase activity
regulation of adenylate cyclase activity
negative regulation of response to drug
positive regulation of filopodium assembly
regulation of cellular response to drug
response to electrical stimulus
regulation of cyclase activity
regulation of filopodium assembly
regulation of lyase activity
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of response to drug
positive regulation of plasma membrane bounded cell projection assembly
regulation of cell shape
protein localization to plasma membrane
basolateral plasma membrane
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
protein localization to cell periphery
developmental maturation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
postsynaptic density
cytoplasmic vesicle
synapse organization
axon
cellular response to abiotic stimulus
cellular response to environmental stimulus
positive regulation of cell projection organization