PAM [The Human Chemical-Genetic Interaction Map Project]

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======= PAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAM
  * **<color #00a2e8>Official Name</color>**: peptidylglycine alpha-amidating monooxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5066|5066]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19021|P19021]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/170270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cu2 monooxygen|
|NHL|
|Cu2 monoox C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty acid primary amide metabolic process|
|peptidylglycine monooxygenase activity|
|peptidylamidoglycolate lyase activity|
|protein amidation|
|fatty acid primary amide biosynthetic process|
|peptide amidation|
|peptide modification|
|L-ascorbic acid binding|
|toxin metabolic process|
|response to pH|
|transport vesicle membrane|
|ovulation cycle process|
|lactation|
|response to copper ion|
|secondary metabolic process|
|copper ion binding|
|maternal process involved in female pregnancy|
|ovulation cycle|
|body fluid secretion|
|fatty acid derivative biosynthetic process|
|secretory granule membrane|
|long-chain fatty acid metabolic process|
|odontogenesis|
|mammary gland development|
|perikaryon|
|response to estradiol|
|response to glucocorticoid|
|response to corticosteroid|
|fatty acid derivative metabolic process|
|trans-Golgi network|
|female pregnancy|
|limb development|
|appendage development|
|multi-multicellular organism process|
|rhythmic process|
|neuron projection|
|fatty acid metabolic process|
|response to steroid hormone|
|protein homooligomerization|
|response to hypoxia|
|regulation of actin cytoskeleton organization|
|response to decreased oxygen levels|
|response to metal ion|
|response to oxygen levels|
|regulation of actin filament-based process|
|gland development|
|protein kinase binding|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of body fluid levels|
|protein complex oligomerization|
|heart development|
|amide biosynthetic process|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|regulation of cytoskeleton organization|
|lipid biosynthetic process|
|cell surface|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|cellular amide metabolic process|
|regulation of secretion|
|multicellular organismal reproductive process|
|zinc ion binding|
|multicellular organism reproduction|
|response to lipid|
|circulatory system development|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|oxidation-reduction process|
|central nervous system development|
|multi-organism reproductive process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|secretion|
|response to abiotic stimulus|
|lipid metabolic process|
|regulation of organelle organization|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17539
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAM Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>