PAM

Entrez Summary: This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fatty acid primary amide metabolic process
peptidylglycine monooxygenase activity
peptidylamidoglycolate lyase activity
protein amidation
fatty acid primary amide biosynthetic process
peptide amidation
peptide modification
L-ascorbic acid binding
toxin metabolic process
response to pH
transport vesicle membrane
ovulation cycle process
lactation
response to copper ion
secondary metabolic process
copper ion binding
maternal process involved in female pregnancy
ovulation cycle
body fluid secretion
fatty acid derivative biosynthetic process
secretory granule membrane
long-chain fatty acid metabolic process
odontogenesis
mammary gland development
perikaryon
response to estradiol
response to glucocorticoid
response to corticosteroid
fatty acid derivative metabolic process
trans-Golgi network
female pregnancy
limb development
appendage development
multi-multicellular organism process
rhythmic process
neuron projection
fatty acid metabolic process
response to steroid hormone
protein homooligomerization
response to hypoxia