PANX3

Entrez Summary: N/A
UniProt Summary: Structural component of the gap junctions and the hemichannels.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

wide pore channel activity
gap junction hemi-channel activity
protein hexamerization
gap junction
positive regulation of interleukin-1 secretion
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
regulation of interleukin-1 production
positive regulation of cytokine secretion
regulation of cytokine secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
protein complex oligomerization
regulation of cytokine production
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
cation transport
positive regulation of transport
regulation of protein localization
cell-cell signaling
transmembrane transport
ion transport
protein-containing complex assembly
positive regulation of multicellular organismal process
protein-containing complex subunit organization
regulation of transport