PAOX
Gene Information
- Official Symbol: PAOX
- Official Name: polyamine oxidase
- Aliases and Previous Symbols: N/A
- Entrez ID: 196743
- UniProt: Q6QHF9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Amino oxidase |
GO Terms
| positive regulation of spermidine biosynthetic process |
| N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| regulation of polyamine biosynthetic process |
| spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity |
| N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| spermidine catabolic process |
| regulation of spermidine biosynthetic process |
| N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| spermine catabolic process |
| spermine:oxygen oxidoreductase (spermidine-forming) activity |
| polyamine oxidase activity |
| putrescine catabolic process |
| polyamine catabolic process |
| spermine metabolic process |
| putrescine biosynthetic process |
| putrescine metabolic process |
| positive regulation of cellular amine metabolic process |
| spermidine metabolic process |
| polyamine biosynthetic process |
| polyamine metabolic process |
| amine catabolic process |
| cellular biogenic amine catabolic process |
| cellular biogenic amine biosynthetic process |
| amine biosynthetic process |
| peroxisomal matrix |
| cellular biogenic amine metabolic process |
| cellular amine metabolic process |
| amine metabolic process |
| protein targeting to peroxisome |
| protein localization to peroxisome |
| establishment of protein localization to peroxisome |
| peroxisomal transport |
| peroxisome organization |
| regulation of cellular amine metabolic process |
| oxidoreductase activity |
| drug catabolic process |
| ammonium ion metabolic process |
| protein targeting |
| establishment of protein localization to organelle |
| drug metabolic process |
| protein localization to organelle |
| oxidation-reduction process |
| intracellular protein transport |
| organonitrogen compound catabolic process |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dimethyl-Sulfoxide 1pc R03 exp120 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15400
- Expression level (log2 read counts): 1.27
Expression Distribution
PAOX Expression in NALM6 Cells: 1.27
