PAPD7

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269|PubMed:23376078}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CFI-400945 25μM R08 exp469	-1.91
Vemurafenib 6.6μM R08 exp434	-1.74

NTP transf 2
PAP assoc

SMC family protein binding
snoRNA polyadenylation
ncRNA polyadenylation
guanylyltransferase activity
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of 3-UTR-mediated mRNA stabilization
regulation of 3-UTR-mediated mRNA stabilization
TRAMP complex
RNA 3 uridylation
polynucleotide adenylyltransferase activity
snoRNA 3-end processing
snoRNA processing
regulation of nuclear-transcribed mRNA poly(A) tail shortening
histone mRNA catabolic process
snoRNA metabolic process
mitotic chromosome condensation
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
histone mRNA metabolic process
RNA polyadenylation
chromosome condensation
sister chromatid cohesion
ncRNA 3-end processing
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
negative regulation of mRNA metabolic process
mitotic sister chromatid segregation
RNA 3-end processing
sister chromatid segregation
mitotic nuclear division
DNA packaging
regulation of mRNA stability
double-strand break repair
regulation of RNA stability
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
mRNA catabolic process
nuclear chromosome segregation
nuclear membrane
RNA catabolic process