PARD6G

Entrez Summary: N/A
UniProt Summary: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PB1
PDZ

Rho GTPase binding
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
protein kinase C binding
centrosome cycle
microtubule organizing center organization
cell-cell junction assembly
bicellular tight junction
cell cortex
cell-cell junction organization
cell junction assembly
establishment or maintenance of cell polarity
cell junction organization
apical plasma membrane
microtubule cytoskeleton organization
cell division
protein-containing complex
microtubule-based process
regulation of cellular localization
cell cycle process
cytoskeleton organization
cell cycle