PARP14

Gene Information

Official Symbol: PARP14
Official Name: poly(ADP-ribose) polymerase family member 14
Aliases and Previous Symbols: N/A
Entrez ID: 54625
UniProt: Q460N5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016].
UniProt Summary: ADP-ribosyltransferase (PubMed:16061477, PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). Mono-ADP- ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP- ribosylates PARP9 (PubMed:27796300). {ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:27796300}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12890
Expression level (log2 read counts): 7.48

Expression Distribution

Screen	Score
Diepoxybutane 3μM R07 exp354	-1.91
Olaparib 4μM R08 exp512	2.68

PARP
Macro

positive regulation of interleukin-4-mediated signaling pathway
regulation of interleukin-4-mediated signaling pathway
negative regulation of response to interferon-gamma
negative regulation of interferon-gamma-mediated signaling pathway
protein mono-ADP-ribosylation
negative regulation of tyrosine phosphorylation of STAT protein
protein ADP-ribosylase activity
negative regulation of receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via STAT
regulation of interferon-gamma-mediated signaling pathway
regulation of response to interferon-gamma
NAD+ ADP-ribosyltransferase activity
protein ADP-ribosylation
positive regulation of cytokine-mediated signaling pathway
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of innate immune response
positive regulation of response to cytokine stimulus
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
negative regulation of response to biotic stimulus
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
negative regulation of immune response
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of defense response
negative regulation of multi-organism process
regulation of peptidyl-tyrosine phosphorylation
enzyme binding
negative regulation of response to external stimulus
negative regulation of protein phosphorylation
negative regulation of immune system process
negative regulation of phosphorylation
regulation of innate immune response
regulation of response to biotic stimulus