PARP9

Gene Information

Official Symbol: PARP9
Official Name: poly(ADP-ribose) polymerase family member 9
Aliases and Previous Symbols: N/A
Entrez ID: 83666
UniProt: Q8IXQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP- ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP- ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300). {ECO:0000250|UniProtKB:Q8CAS9, ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28525742}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15989
Expression level (log2 read counts): 5.76

Expression Distribution

ADP-D-ribose binding
positive regulation of interferon-gamma-mediated signaling pathway
positive regulation of response to interferon-gamma
protein poly-ADP-ribosylation
STAT family protein binding
positive regulation of double-strand break repair via nonhomologous end joining
positive regulation of chromatin binding
NAD biosynthesis via nicotinamide riboside salvage pathway
NAD+ binding
site of DNA damage
ubiquitin-like protein ligase binding
regulation of chromatin binding
regulation of double-strand break repair via nonhomologous end joining
regulation of response to interferon-gamma
regulation of interferon-gamma-mediated signaling pathway
positive regulation of defense response to virus by host
NAD+ ADP-ribosyltransferase activity
NAD biosynthetic process
protein ADP-ribosylation
enzyme inhibitor activity
positive regulation of double-strand break repair
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
regulation of defense response to virus by host
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
positive regulation of DNA repair
positive regulation of tyrosine phosphorylation of STAT protein
regulation of defense response to virus
positive regulation of protein localization to nucleus
regulation of double-strand break repair
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
positive regulation of response to DNA damage stimulus