PARPBP

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM131593 0.2μM R03 exp106	-1.78
proTAME 5μM R04 exp187	1.85

negative regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair
negative regulation of DNA repair
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
regulation of DNA recombination
chromatin
negative regulation of DNA metabolic process
regulation of DNA repair
regulation of response to DNA damage stimulus
regulation of DNA metabolic process
DNA repair
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of nucleobase-containing compound metabolic process
DNA binding
regulation of response to stress
negative regulation of response to stimulus
cellular response to stress