PATL1

Entrez Summary: N/A
UniProt Summary: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
LSM1	0.438
HGC6.3	0.422

poly(G) binding
deadenylation-dependent decapping of nuclear-transcribed mRNA
cytoplasmic mRNA processing body assembly
CCR4-NOT complex
poly(U) RNA binding
exonucleolytic catabolism of deadenylated mRNA
nuclear-transcribed mRNA catabolic process, exonucleolytic
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cytoplasmic ribonucleoprotein granule
P-body
PML body
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
nucleobase-containing compound catabolic process
nuclear speck
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
organic cyclic compound catabolic process
mRNA metabolic process
organelle assembly
cellular protein-containing complex assembly
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
protein-containing complex assembly
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization