PATL2

Gene Information

Official Symbol: PATL2
Official Name: PAT1 homolog 2
Aliases and Previous Symbols: N/A
Entrez ID: 197135
UniProt: C9JE40
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: RNA-binding protein that acts as a translational repressor. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6381
Expression level (log2 read counts): 2.42

Expression Distribution

negative regulation of cytoplasmic mRNA processing body assembly
deadenylation-dependent decapping of nuclear-transcribed mRNA
regulation of cytoplasmic mRNA processing body assembly
cytoplasmic mRNA processing body assembly
negative regulation of organelle assembly
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
P-body
negative regulation of translation
negative regulation of protein complex assembly
negative regulation of cellular amide metabolic process
ribonucleoprotein complex
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
regulation of organelle assembly
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
regulation of translation
negative regulation of organelle organization
nucleobase-containing compound catabolic process
regulation of cellular amide metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
regulation of protein complex assembly
ribonucleoprotein complex biogenesis
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
mRNA metabolic process
negative regulation of cellular component organization
organelle assembly
cellular protein-containing complex assembly
cellular macromolecule catabolic process
regulation of cellular component biogenesis
negative regulation of cellular protein metabolic process
macromolecule catabolic process
negative regulation of protein metabolic process
regulation of organelle organization
negative regulation of cellular macromolecule biosynthetic process
RNA binding