PBK

Gene Information

Official Symbol: PBK
Official Name: PDZ binding kinase
Aliases and Previous Symbols: N/A
Entrez ID: 55872
UniProt: Q96KB5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9970
Expression level (log2 read counts): 5.96

Expression Distribution

Screen	Score
UM131593 0.2μM R03 exp106	-1.7
INK128 0.2μM R02 exp70	1.74

Pkinase Tyr
Pkinase

negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
cellular response to UV
negative regulation of cellular protein catabolic process
cellular response to light stimulus
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
negative regulation of inflammatory response
response to UV
regulation of ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
cellular response to radiation
regulation of proteasomal protein catabolic process
negative regulation of defense response
regulation of proteolysis involved in cellular protein catabolic process
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
response to light stimulus
negative regulation of catabolic process
cellular response to abiotic stimulus
cellular response to environmental stimulus
regulation of inflammatory response
negative regulation of proteolysis
protein serine/threonine kinase activity
negative regulation of response to external stimulus
regulation of protein catabolic process
negative regulation of protein phosphorylation
response to radiation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mitotic cell cycle