PBLD

Gene Information

Official Symbol: PBLD
Official Name: phenazine biosynthesis like protein domain containing
Aliases and Previous Symbols: N/A
Entrez ID: 64081
UniProt: P30039
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17720
Expression level (log2 read counts): 3.92

Expression Distribution

Screen	Score
Vitamin-D3 40μM R08 exp536	-1.79
Hydroxychloroquine 30μM R08 exp490	1.85

negative regulation of SMAD protein signal transduction
negative regulation of pathway-restricted SMAD protein phosphorylation
isomerase activity
maintenance of gastrointestinal epithelium
regulation of SMAD protein signal transduction
negative regulation of epithelial to mesenchymal transition
epithelial structure maintenance
regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of epithelial cell migration
digestive system process
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of epithelial to mesenchymal transition
digestion
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of epithelial cell proliferation
negative regulation of cellular response to growth factor stimulus
tissue homeostasis
regulation of epithelial cell migration
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell migration
regulation of cellular response to growth factor stimulus
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
multicellular organismal homeostasis
regulation of epithelial cell proliferation
anatomical structure homeostasis
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of cell population proliferation
negative regulation of cell differentiation
molecular function
regulation of cell migration
regulation of cell motility