PBRM1 [The Human Chemical-Genetic Interaction Map Project]

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======= PBRM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PBRM1
  * **<color #00a2e8>Official Name</color>**: polybromo 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55193|55193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86U86|Q86U86]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PBRM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PBRM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
|HMG box|
|BAH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RSC-type complex|
|DNA translocase activity|
|nucleosome disassembly|
|chromatin disassembly|
|protein-DNA complex disassembly|
|nuclear chromosome|
|transcription elongation from RNA polymerase II promoter|
|ATP-dependent chromatin remodeling|
|DNA-templated transcription, elongation|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|chromatin binding|
|cellular component disassembly|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|chromatin organization|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-4.02|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-3.91|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-3.48|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-3.18|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.76|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.6|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.44|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.26|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.21|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.21|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.09|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.08|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.08|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.94|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.94|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.88|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.86|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.84|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.8|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.76|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.7|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brd7|BRD7]]|0.59|
|[[:human genes:p:polr2j3|POLR2J3]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14410
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PBRM1 Expression in NALM6 Cells: 7.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>