PBRM1

Entrez Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-4.02
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-3.91
THZ531 0.11μM R07 exp409	-3.48
THZ531 0.11 to 0.175μM on day4 R07 exp413	-3.18
Tubacin 1.6μM R07 exp416	-2.76
Calcium Ionophore 0.4μM R07 exp342	-2.74
Genistein 15μM R07 exp360	-2.6
MLN-4924 0.2μM R00 exp21	-2.44
Nifuroxazide 5μM R03 exp102	-2.26
Senexin-A 25μM R07 exp400	-2.21
THZ531 0.225μM R08 exp444	-2.21
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.09
LY2090314 0.003μM R08 exp500 no dilution day6	-2.08
ONC212 0.15μM R08 exp513	-2.08
CR131-b 0.005μM R08 exp474	-1.94
GSK461364A 0.1μM R03 exp126	-1.94
Lead acetate 2000μM R08 exp498 no dilution day6	-1.89
BI-6727 0.0125μM R03 exp97	-1.88
Nutlin-3A 1.6μM R06 exp294	-1.86
UM0125461 0.74μM R02 exp84	-1.86
Hippuristanol 0.12μM R08 exp488	-1.84
FK-506 30μM R07 exp359	-1.8
BI-D1870 3.15μM R02 exp66	-1.76
Oligomycin-A 2μM R00 exp25	-1.76
Wiskostatin 3μM R07 exp422	-1.7
Hypoxia 5%O2 R04 exp191	2.25

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

Gene	Correlation
BRD7	0.59
POLR2J3	0.435

RSC-type complex
DNA translocase activity
nucleosome disassembly
chromatin disassembly
protein-DNA complex disassembly
nuclear chromosome
transcription elongation from RNA polymerase II promoter
ATP-dependent chromatin remodeling
DNA-templated transcription, elongation
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
protein-containing complex disassembly
protein-DNA complex subunit organization
chromatin binding
cellular component disassembly
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
negative regulation of cell population proliferation
mitotic cell cycle
chromatin organization
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
DNA binding
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression