PCBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= PCBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCBP2
  * **<color #00a2e8>Official Name</color>**: poly(rC) binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5094|5094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15366|Q15366]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KH 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-rich single-stranded DNA binding|
|IRES-dependent viral translational initiation|
|viral translation|
|viral RNA genome replication|
|negative regulation of defense response to virus|
|viral genome replication|
|negative regulation of type I interferon production|
|regulation of defense response to virus|
|negative regulation of response to biotic stimulus|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|viral gene expression|
|defense response to virus|
|viral life cycle|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|postsynaptic density|
|negative regulation of cytokine production|
|response to virus|
|ubiquitin protein ligase binding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|enzyme binding|
|proteasomal protein catabolic process|
|negative regulation of response to external stimulus|
|RNA splicing|
|focal adhesion|
|negative regulation of immune system process|
|regulation of immune effector process|
|mRNA processing|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of cytokine production|
|mRNA metabolic process|
|viral process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|defense response to other organism|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.23|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.03|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.97|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.62|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.62|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.58|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.44|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.37|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.21|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.18|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.08|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.05|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.99|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.99|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.97|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.92|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.91|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.86|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.79|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.74|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.76|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.8|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.87|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.91|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.92|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.02|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.11|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.2|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.21|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.31|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.31|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.52|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.71|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.87|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.11|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.42|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.567|
|[[:human genes:e:eny2|ENY2]]|0.433|
|[[:human genes:t:tgs1|TGS1]]|0.415|
|[[:human genes:g:gfpt1|GFPT1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 716/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/26|
|breast|32/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCBP2 Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>