PCBP2
Gene Information
- Official Symbol: PCBP2
- Official Name: poly(rC) binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5094
- UniProt: Q15366
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| KH 1 |
GO Terms
| C-rich single-stranded DNA binding |
| IRES-dependent viral translational initiation |
| viral translation |
| viral RNA genome replication |
| negative regulation of defense response to virus |
| viral genome replication |
| negative regulation of type I interferon production |
| regulation of defense response to virus |
| negative regulation of response to biotic stimulus |
| negative regulation of immune effector process |
| regulation of type I interferon production |
| viral gene expression |
| defense response to virus |
| viral life cycle |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| postsynaptic density |
| negative regulation of cytokine production |
| response to virus |
| ubiquitin protein ligase binding |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| RNA splicing, via transesterification reactions |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| enzyme binding |
| proteasomal protein catabolic process |
| negative regulation of response to external stimulus |
| RNA splicing |
| focal adhesion |
| negative regulation of immune system process |
| regulation of immune effector process |
| mRNA processing |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| regulation of cytokine production |
| mRNA metabolic process |
| viral process |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| RNA processing |
| cellular macromolecule catabolic process |
| defense response to other organism |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of multicellular organismal process |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| RNA binding |
| regulation of response to stress |
| negative regulation of response to stimulus |
| regulation of immune system process |
| RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| immune response |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 716/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 28/28 |
| bone | 23/26 |
| breast | 32/33 |
| central nervous system | 52/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 73/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 3128
- Expression level (log2 read counts): 8.76
Expression Distribution
PCBP2 Expression in NALM6 Cells: 8.76
