PCDH15

Entrez Summary: This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

equilibrioception
stereocilium
photoreceptor cell maintenance
neuromuscular process controlling balance
photoreceptor outer segment
retina homeostasis
neuromuscular process
sensory perception of sound
sensory perception of mechanical stimulus
homophilic cell adhesion via plasma membrane adhesion molecules
tissue homeostasis
inner ear development
ear development
sensory perception of light stimulus
cell-cell adhesion via plasma-membrane adhesion molecules
synapse
multicellular organismal homeostasis
anatomical structure homeostasis
cell-cell adhesion
sensory organ development
calcium ion binding
cell adhesion
biological adhesion
sensory perception
nervous system process
integral component of plasma membrane
homeostatic process
extracellular region
system process